Periodontal microorganisms and diagnosis of malignancy: A cross-sectional study

BACKGROUND: Oral infections associate statistically with cancer. OBJECTIVE: We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out investigate this our ongoing cohort study. METHODS: A sample of 99 clinically examined patients from 1676 subjects was used the associations between harboring Aggregatibacter actinomycetemcomitans (A.a), Porphyromonas gingivalis (P.g), Prevotella intermedia (P.i), Tannerella forsythia (T.f) Treponema denticola (T.d). oral infection indexes incidence figures as registered 2008–2016 Swedish National Cancer Register. RESULTS: The pathogen A.a showed strong association malignancy 32 while P.g P.i were more prevalent among without malignancy. In principal component analyses, appeared strongest second consisted a combination T.f T.d. third P.i, respectively. Of basic health variables, gingival index be expression inflammation (Eigen value 4.11 Explained Variance 68.44 percent). CONCLUSIONS: results partly confirmed hypothesis by showing bacteria However, are statistical no conclusions can drawn about causality.